Optimsing the Outcomes of PPCI

Impaired myocardial perfusion is not uncommon following primary PcI and results in a larger infarct size and increased mortality.4 A number of device-based or pharmacologic strategies have been studied to reduce the final infarct size. The devicebased strategies are simple aspiration catheters, thrombectomy devices and distal protection devices. The pharmacologic therapies that are recently being investigated and established are intracoronary or intravenous administration of fibrinolytic or Gp IIb/IIIa inhibitors or administration of new oral antiplatelet drugs.5 repair of infarcted myocardium with stem cell therapy is an additional modality which has produced mixed results so far. Following review will discusses the recent advances in the management of AMI (Figure 1).